Cisco SecureX [EOL] vs Microsoft Defender for Cloud comparison

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Cisco and Microsoft are both solutions in the Vulnerability Management category. Additionally, 100% of Cisco users are willing to recommend the solution, compared to 94% of Microsoft users who would recommend it.

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Executive SummaryUpdated on Nov 2, 2025

Cisco SecureX [EOL] and Microsoft Defender for Cloud are competitors in the cybersecurity management domain, providing comprehensive security solutions. Microsoft Defender for Cloud appears to have the upper hand due to its advanced threat protection and broad workload coverage.

Features: Cisco SecureX [EOL] offers a unified dashboard providing visibility across sites and endpoints, alongside sophisticated threat-hunting capabilities. It integrates seamlessly with Cisco and third-party products for coordinated threat responses and provides automated malware categorization. Microsoft Defender for Cloud excels in vulnerability management, coordinated detection, and response across environments. Its seamless integration with Microsoft Sentinel enhances visibility and provides prioritized security recommendations for diverse workloads.

Room for Improvement: Cisco SecureX [EOL] can improve through enhanced automation features, more straightforward orchestration, and expanded integration options with third-party products to increase deployment flexibility. Microsoft Defender for Cloud may benefit from clearer attack path mapping, better handling of security recommendations, and a simplified pricing model to improve user experience by reducing complexity and false positives.

Ease of Deployment and Customer Service: Cisco SecureX [EOL] facilitates deployment across Public Cloud, Private Cloud, and On-premises environments, with users highlighting fast and efficient support services. Meanwhile, Microsoft Defender for Cloud caters to diverse cloud setups, including Public and Hybrid Clouds. It offers substantial support resources, though some users find initial setup support slower than Cisco’s prompt response.

Pricing and ROI: Cisco SecureX [EOL] provides significant ROI as a free add-on with any Cisco security product, leading to increased operational efficiency and reduced manual workload. Its pricing is considered justified given the level of integration and support. Microsoft Defender for Cloud, while competitive, is perceived as costly by some users, particularly for smaller businesses and comprehensive workload coverage. Despite this, it reports positive ROI with improved threat detection and response capabilities, making its cost justifiable for many customers.

To learn more, read our detailed Vulnerability Management Report (Updated: September 2026).

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September 2026

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Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Categories and Ranking

Qualys TotalCloud

Featured Reviews

reviewer2859021

Sr Security Engineer at a tech vendor with 5,001-10,000 employees

Risk-based triage has transformed container security and now prioritizes high-impact threats

The best features Qualys TotalCloud offers currently include managing cloud infrastructure and container security while facing major challenges such as alert fatigue. Traditional vulnerability scanners flag hundreds of CVEs on short-lived Kubernetes containers, some of which have no internet exposure or are gone before we can even triage them. I leverage Qualys TotalCloud to move beyond static CVSS. I use it to implement runtime exposure, correlation risk reprioritization, and shift-left integration. This notifies developers to fix a base image upstream rather than patching live ephemeral instances. In my work with cloud and container security, the biggest operational hurdle was alert fatigue. I use Qualys to shift left from static CVSS severity to context-aware risk prioritization. I correlated raw vulnerability data with real-time risk factors such as public network exposure, active runtime execution, or overly permissive IAM roles. This allows us to immediately drop the priority of isolated containers and escalate lower-severity CVEs that sit on an exposed, high-risk path. We can map these findings directly back to our CI/CD pipelines so developers can patch the root base images upstream. We have drastically cut down the signal-to-noise ratio, saved a lot of manual hours doing triage work, and ensured engineering effort goes directly towards high-impact risk reduction.

Read full review

Dene Lewis

Head of Technical Strategy and Direction CAE Technology Services Ltd at CAE Technology Services Limited

A scalable SaaS based platform that helps with cyber threat intelligence and automated hunting

I would rate Cisco SecureX a ten out of ten. I find the product to be a fantastic platform. If you are eligible, start using it straight away. The best way to evaluate it is to start using it and see where it fits within your organization. I think it helps our customers really deliver their SecOps goals, and I see it as a core foundation of CAE's own security strategy going forward. Our partnership with Cisco is one that was built on trust over a long period of time. This has enabled us to work together to be able to provide the solutions that our customers need to drive their organizations forward. The value we add as a reseller is being able to work closer with our customers, understand them, and get intimate with their organizations. That enables us to offer them the right solutions that will help them achieve their goals.

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RyanWalker

Head Of IT at Cirrus Response

Cloud security has cut investigation time and now reveals threats faster but needs simpler oversight

When deploying AI applications, my key security concerns with Microsoft Defender for Cloud are data loss, leakage of data, and guardrails around the actual AI, and I am hoping that this is going to help me put those guardrails in place and identify data exfiltration. Microsoft Defender for Cloud has not helped me manage and secure multi-cloud environments, as we are 100 percent Microsoft and have not really got it in any other environment at all. I am not yet using the unified AI-powered security feature offered by Microsoft Defender for Cloud, but that is coming. I am not yet using the integrated XDR feature of Microsoft Defender for Cloud, but that is coming. I am not yet utilizing the GenAI threat protection features of Microsoft Defender for Cloud. That is also coming and a lot of that will come from learning it here. I have enabled the agentless scanning in my cloud environment with Microsoft Defender for Cloud. Assessing the impact on my workload protection without needing to install agents with Microsoft Defender for Cloud makes it a lot easier, but it also identifies a lot more, which puts more load on me sometimes. I would advise another organization considering Microsoft Defender for Cloud that it is the most logical route to follow if their whole ecosystem is Microsoft. It is easy to implement and it is very self-explanatory when doing it, making sense to just follow the steps as it is too simple, really. I would rate this review a 7.5 out of 10.

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Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:

Pros

"Qualys TotalCloud helps you not just to identify misconfigurations, but you can actually also fix issues."

"Qualys TotalCloud's most valuable feature is its agent versatility."

"Its dashboards are brilliant. It provides in-depth insights."

"The most valuable feature is the consolidated information that it provides from various platforms."

"I would definitely recommend Qualys TotalCloud to other customers."

"I would recommend Qualys TotalCloud to other users because it is cost-efficient and has a good return on investment."

"The dashboards are particularly valuable as they offer a comprehensive view of the environment, highlighting any misconfigurations."

"I rate the breadth of FlexScan in providing visibility into on-premises, multicloud, and container environments as fantastic."

More Qualys TotalCloud pros

"SecureX takes all the separate pieces of security within your company, adds in intelligence from different sites and services on the internet, and makes them work together."

"Integrates well with our existing security infrastructure."

"The forensics are amazing because when you have enrichment, and the solutions talk with each other, when you need it, you have the ability to know everything in the organization: when, why, whatever."

"Using SecureX, a tool provided by Cisco, we can easily integrate it with many of our other Cisco products such as Cisco ISE and many networking devices."

"SecureX definitely provides us with contextual awareness throughout our security ecosystem, since it allows us to integrate multiple threat intelligence feeds, as well as multiple security appliances and platforms."

"SecureX has been keeping our devices safe during the pandemic and we haven't had any major threats that have come in or that have been found on our devices."

"This solution definitely helps us meet our cyber security goals and we haven't had any problems so far."

"The most beneficial feature of Cisco SecureX for cybersecurity efforts is its integration with other Cisco solutions and the environment. This sets it apart, as its APIs and overall integration capabilities are very strong. Additionally, its detection capabilities are commendable."

More Cisco SecureX [EOL] pros

"I would rate Microsoft Defender for Cloud a nine out of 10."

"I would rate Microsoft Defender for Cloud a ten out of ten."

"I appreciate the features of Microsoft Defender for Cloud the most because it incorporates itself into the entire Microsoft platform, and it's a one-stop shop for administration in the web."

"The most valuable features are the security recommendations provided by Defender for Cloud."

"When you have commissioned Defender, you have these things visible already on your dashboard. This gives the efficiency to the people to do their actual work rather than bothering about the email, sorting out the email, or looking at it through an ITSM solution, whey they have to look at the description and use cases. Efficiency increases with this optimized, ready-made solution since you don't need to invest in something externally. You can start using the dashboard and auditing capability provided from day one. Thus, you have fewer costs with a more optimized, easier-to-use solution, providing operational efficiency for your team."

"The most valuable feature is the recommendations provided on how to improve security. It has made the cloud environment more secure, thanks to all the recommendations we can get."

"Microsoft Defender for Cloud is a valuable tool that integrates seamlessly with Azure Policy and our Security SIEM, simplifying implementation and enhancing security posture."

"The most valuable feature for me is the variety of APIs available."

More Microsoft Defender for Cloud pros

Cons

"The price is very expensive, actually."

"We would like to see Windows-based sensors available in Qualys, as this would make the platform more versatile and support a broader range of environments."

"I sometimes have difficulty detecting or uninstalling certain versions of applications, which I have to do manually."

"Customer support with Qualys TotalCloud needs a little improvement with the response times."

"Their customer support needs improvement."

"In my opinion, what can be improved in Qualys TotalCloud includes pricing and container scanning."

"Two areas for improvement in Qualys TotalCloud are the speed of the public cloud platform and vulnerability detection."

"Qualys's ticketing system can be confusing when assigning tasks to individuals, and support could be improved by offering instant call solutions with engineers in addition to ticket replies."

More Qualys TotalCloud cons

"Enhancing automation capabilities could further improve the product."

"They could expand into more areas."

"Remediation stuff could be integrated into the product's automation."

"They could put in more third-party [integrations]... also more playbooks, out-of-the-box, for automation [would be helpful]."

"Sometimes it's a little slow so that is also something Cisco should check."

"The front-end work controls the new algorithm and the firewall rules. The search feature of these rules could be improved."

"I'm not sure that I would call it a bug, but sometimes the solution is a little slow."

"If they could make the Cisco Umbrella piece a little bit more advanced or easier to manage, that would help. We use it for filtering and when you compare it to a normal content filter, it lacks some functionality."

More Cisco SecureX [EOL] cons

"Another thing is that Defender for Cloud uses more resources than CrowdStrike, which my current company uses. Defender for Cloud has two or three processes running simultaneously that consume memory and processor time. I had the chance to compare that with CrowdStrike a few days ago, which was significantly less. It would be nice if Defender were a little lighter. It's a relatively large installation that consumes more resources than competitors do."

"Microsoft Defender for Cloud could be improved by adding capabilities for NetApp files and more PaaS resources from other vendors, not just Microsoft."

"I don't appreciate Microsoft Defender for Cloud because it seems to interfere with many things. That's the problem I've been experiencing with it."

"I would like to see more connectors and plugins with other platforms."

"With the new Copilot functionality available everywhere, it is challenging to pinpoint areas for improvement. If I put in a lot of thought, I might identify things, but right now, nothing significant pops into my mind, but there is always room for more transparency, especially in pricing."

"It's hard to reach someone who understands my problems. I haven't had many issues, so I haven't called them."

"Customer service and support from Microsoft are very poor. Even for high-severity cases, response or resolution time can extend to three or four weeks."

"There are many unknowns with AI applications. AI agents will operate while you're not present, whether you are sleeping or awake, and it's unclear whether there would be any exfiltration of data or how data is being managed."

More Microsoft Defender for Cloud cons

Pricing and Cost Advice

"Qualys TotalCloud is expensive."

"The pricing is comparable. It is built into our other product, so I cannot piecemeal it. It is a part of our subscription."

"I am not sure about the pricing. From what I understand, it is a bit on the higher side, but I do not have the exact numbers."

"TotalCloud's price is about right where I would expect it to be."

"The pricing for TotalCloud is attractive and competitive in the market. Given the features, especially the dashboard, I have no concerns regarding pricing."

"While Qualys TotalCloud's pricing is currently acceptable, it is becoming increasingly expensive and may soon be considered overpriced."

"Although Qualys TotalCloud is relatively expensive due to its unique automation features, its cost-effectiveness is rated an eight out of ten, with ten being the most costly."

"The cost is high, but it meets our organizational needs."

More Qualys TotalCloud pricing and cost advice

"It comes free with all Cisco products. So, it is a good price."

"For the value you get, the pricing of the solution is excellent."

"The pricing is the best part of this solution. It is free if you buy Umbrella or Duo Security. It is also a good solution."

"The product is absolutely free to any customer. As such, the only thing one must keep in mind is that as long as he already has one Cisco security product, irregardless of what that product is, SecureX is available for free."

"It would be nice if they had a different pricing model. Most of our budget for projects goes towards Cisco."

"Cisco SecureX is more expensive than Trend Micro. However, considering the integration capabilities with other solutions and the quality of technical support, I believe there's justification for the price difference."

"The pricing is competitive, especially for education institutions. Licensing can be a little bit difficult to navigate, especially with resellers with Cisco, but for us it has been pretty easy."

"It is free. It can't get any better than that."

More Cisco SecureX [EOL] pricing and cost advice

"There is a helpful cost-reducing option that allows you to integrate production subscriptions with non-production subscriptions."

"I'm not privy to that information, but I know it's probably close to a million dollars a year."

"Microsoft Defender for Cloud is pricey, especially for Kubernetes clusters."

"Our clients complain about the cost of Microsoft Defender for Cloud."

"Pricing is a consideration, but we strive to keep costs low by enabling only necessary services."

"This solution is more cost-effective than some competing products. My understanding is that it is based on the number of integrations that you have, so if you have fewer subscriptions then you pay less for the service."

"I am not involved much with the pricing but the bundle offering is good."

"Defender for Cloud is pretty costly for a single line. It's incredibly high to pay monthly for security per server. The cost is considerable for an enterprise with 500-plus virtual machines, and the monthly bill can spike."

More Microsoft Defender for Cloud pricing and cost advice

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Top Industries

By visitors reading reviews

Comms Service Provider

18%

Outsourcing Company

12%

Manufacturing Company

11%

Financial Services Firm

10%

Outsourcing Company

23%

Construction Company

12%

Marketing Services Firm

Manufacturing Company

Financial Services Firm

11%

Computer Software Company

Manufacturing Company

Outsourcing Company

Company Size

By reviewers

Large Enterprise

Midsize Enterprise

Small Business

By reviewers
Company Size	Count
Small Business	16
Midsize Enterprise	10
Large Enterprise	38

By reviewers
Company Size	Count
Small Business	4
Midsize Enterprise	7
Large Enterprise	3

By reviewers
Company Size	Count
Small Business	31
Midsize Enterprise	12
Large Enterprise	49

Questions from the Community

What is your experience regarding pricing and costs for Qualys TotalCloud?

I was not involved in pricing, setup cost, and licensing, but I can say that the setup was fast, within a quarter, an...

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What needs improvement with Qualys TotalCloud?

In terms of improvements, the features we are using in Qualys TotalCloud are working in the best optimal way, and I d...

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What is your primary use case for Qualys TotalCloud?

I have been using Qualys TotalCloud for the last eight months to scan the hardware and the virtual devices in our inf...

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What is your experience regarding pricing and costs for Microsoft Defender for Cloud?

My experience with pricing, setup costs, and licensing was that the license cost was the only consideration. Setup an...

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What needs improvement with Microsoft Defender for Cloud?

To improve Microsoft Defender for Cloud, I think pricing-wise, the license price is a little bit higher from an inges...

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TrendAI Vision One – Cloud Security vs Cisco SecureX [EOL]

Compared 4% of the time

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Compared 4% of the time

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AWS GuardDuty vs Microsoft Defender for Cloud

Compared 20% of the time

Wiz vs Microsoft Defender for Cloud

Compared 3% of the time

SentinelOne Singularity Cloud Security vs Microsoft Defender for Cloud

Compared 2% of the time

Prisma Cloud by Palo Alto Networks vs Microsoft Defender for Cloud

Compared 2% of the time

Microsoft Defender XDR vs Microsoft Defender for Cloud

Compared 1% of the time

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Product Reports

Buyer's Guide

Qualys TotalCloud

October 2026

Download Qualys TotalCloud product report

Buyer's Guide

Cisco SecureX [EOL]

October 2026

Download Cisco SecureX [EOL] product report

Buyer's Guide

Microsoft Defender for Cloud

October 2026

Download Microsoft Defender for Cloud product report

Also Known As

Qualys TotalCloud with FlexScan

Kenna.AppSec, Kenna.VI

Microsoft Azure Security Center, Azure Security Center, Microsoft ASC, Azure Defender

Interactive Demo

Demo not available

Qualys

Demo not available

Cisco

Microsoft

Overview

Qualys TotalCloud enhances security posture across cloud environments with continuous monitoring, vulnerability management, and risk visualization, ensuring efficient threat assessment and automated remediation for improved cyber risk reduction.

Qualys TotalCloud offers a robust suite of security tools essential for organizations managing multi-cloud infrastructures. By integrating cloud accounts and automating workflows, it supports AWS, Azure, and GCP, offering comprehensive vulnerability management and zero-day detection. The platform's user-friendly design, combined with its extensive risk management and unified threat assessment capabilities, enables organizations to prioritize and remediate vulnerabilities effectively. TruRisk Insights provides clear insights on cyber risks, while the automation options streamline patch management and scanning processes. API integration across IaaS and SaaS environments further enhances resource allocation efficiency and saves time, addressing misconfigurations across cloud environments.

What are the most important features of Qualys TotalCloud?

Accurate Vulnerability Reports: Delivers precise and actionable insights for risk mitigation.
Zero-Day Detection: Identifies and addresses zero-day vulnerabilities proactively.
Unified Threat Assessment: Offers comprehensive evaluation of threats across the environment.
Extensive Risk Management: Manages risks effectively with advanced insights and prioritization.
Continuous Monitoring: Provides non-stop surveillance for vulnerabilities and threats.
Cloud-Native Automation: Streamlines processes and reduces manual efforts using automation.
FlexScan for Internet-Facing VMs: Scans external VMs efficiently to detect vulnerabilities.
Dashboard Risk Visualization: Clear visualization helps prioritize vulnerabilities.

What benefits and ROI should users look for?

Improved Security Posture: Enhances threat detection and response across clouds.
Time Savings: Automation reduces time spent on manual vulnerability management.
Resource Efficiency: Better allocation of resources through streamlined workflows.
Enhanced Risk Prioritization: Focus on critical vulnerabilities for effective mitigation.
Integrated Cloud Accounts: Facilitates seamless cloud management and security.

Qualys TotalCloud is deployed in sectors needing rigorous vulnerability management, such as finance and healthcare. Companies utilize it to secure multi-cloud environments like AWS, Azure, and GCP, focus on compliance, and integrate security into CI/CD pipelines to detect and remedy threats pre-deployment.

Qualys

Cisco SecureX is an integrated security platform that connects the breadth of Cisco's integrated security portfolio and the customer's infrastructure to create a consistent experience. The solution unifies visibility, enables automation, and strengthens your security across network, endpoints, cloud, and applications. Cisco SecureX is embedded within every Cisco Security product and supports integrations with SIEM and SOAR, so customers will not need to replace any solution or worry about layering on new technology.

Cisco SecureX Features

Cisco SecureX has many valuable key features. Some of the most useful ones include:

Unified overview: Cisco SecureX offers key metrics on transactions and threats for network, endpoints, cloud and applications. In addition, the SecureX interface is integrated into all Cisco Security technologies.

Automation and an increase in operational efficiency: With Cisco SecureX, you gain better automation of workflows for products of the Cisco Security portfolio and third parties, allowing you to focus on other more important tasks. By eliminating manual work (through automatic identification of threats using analytical data of Cisco Talos and other sources), the solution helps your organization save a significant amount of time.

Security strengthening: Cisco SecureX makes it easy to compare analytical data from a set of various sources with the telemetry received from network, endpoints, e-mail, cloud, and third-party products.

Cisco SecureX Benefits

Some of the benefits of using Cisco SecureX include:

Secure every business endeavor with an open, integrated platform that has out-of-the-box interoperability and scales to meet security needs.

Advance your security maturity level using existing resources.

Turn security from a blocker into an enabler. Cisco SecureX allows you to add new security capabilities for the threat landscape.

Maximize your operational efficiency, helping you get the most from your security investments.

Reviews from Real Users

Below are some reviews and helpful feedback written by Cisco SecureX users.

PeerSpot user Wouter H., Technical Team Lead Network & Security at Missing Piece BV, shares several reasons why he thinks the solution is fantastic. In his opinion, “SecureX takes all the separate pieces of security within your company, adds in intelligence from different sites and services on the internet, and makes them work together. If an email is received on a machine and malware is being executed, it can be put into lockdown mode. The fact that you can have a single solution that combines endpoint intelligence with email intelligence, firewalls, and publicly available intelligence is really helpful. Also, SecureX provides us with contextual awareness throughout our security ecosystem. Before SecureX, things that were not possible, or that would take days, now literally take seconds to find out.

Michal S., Infrastructure Engineer at a media company, says, “SecureX provides many measurements and has a really good dashboard. Working with it you are able to see things very clearly and you have every detail on a single display. That saves us money and time.” He also adds, “It brings all our data into a central point. It also shows us many data connections between many of our environments. SecureX gives you really good information about potential risks. You are able to find the source of a risk, a potential risk from a user or a machine.”

Blair A., Technology Director at Shawnee Heights USD #450, explains, "One of the most valuable features is the simplicity of deploying SecureX. It's very easy to do that and then you gain very detailed visibility into everything that's going on in your network and, obviously, at the device level. There's just a wealth of information that you can pull from all of these products that are part of SecureX. You know exactly if you have an issue or not."

Cisco

Microsoft Defender for Cloud is a comprehensive security platform offering integration with Microsoft services, multi-cloud capability, AI-driven threat detection, compliance, and unified visibility for improved security operations.

Microsoft Defender for Cloud manages security operations by integrating with Microsoft services and supporting multi-cloud environments. Its features include AI-driven threat detection, compliance oversight, and advanced threat protection. It simplifies processes with unified visibility, threat intelligence, and automated workflows, enhancing security posture across various workloads. Despite its robust capabilities, improvements are needed in third-party tool integration, comprehensive AI-driven remediation, and a more intuitive dashboard. Users report complexity in licensing, inadequate documentation, and high costs, with room for enhancements in compliance reporting and multi-cloud support.

What are the key features of Microsoft Defender for Cloud?

Integration with Microsoft Services: Seamlessly integrates with Microsoft platforms for streamlined operations.
Multi-Cloud Capability: Supports various cloud environments for broader coverage.
AI-Driven Threat Detection: Uses AI to identify and counter security threats effectively.
Compliance Features: Offers regulatory compliance tools to ensure adherence to standards.
Unified Visibility: Provides a comprehensive view of security operations for better management.
Code-to-runtime security: Connects to GitHub and development tools so teams can find and fix issues before they reach production.
Advanced Threat Protection: Delivers enhanced defense against complex threats.
Vulnerability Management: Identifies and addresses vulnerabilities proactively.

What benefits and ROI can users expect?

Enhanced Security Posture: Strengthens security across multiple environments.
Unified Threat Intelligence: Centralizes threat data for informed decision-making.
Automated Processes: Streamlines security operations with automated workflows.
Prioritized Remediation: Offers prioritized actions to address security challenges efficiently.

Organizations use Microsoft Defender for Cloud to secure applications from code to runtime across Azure, AWS, Google Cloud, and on-premises environments. Security teams use it to manage cloud security posture, protect servers, containers, and AI workloads, and investigate threats in the Microsoft Defender portal. It provides comprehensive security overviews by monitoring cloud vulnerabilities, limiting unauthorized access, and replacing existing tools with its extensive capabilities from network security to compliance checks, securing Azure infrastructure, and enhancing client security.

Microsoft

Sample Customers

Information Not Available

NHS, Rackspace, UNC Pembroke, University of North Carolina at Charlotte, Missing Piece

Microsoft Defender for Cloud is trusted by companies such as ASOS, Vatenfall, SWC Technology Partners, and more.

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Vulnerability Management

September 2026

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