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Microsoft Defender for Office 365 vs Trend Micro InterScan Messaging Security [EOL] comparison

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Comparison Buyer's Guide

Executive SummaryUpdated on Nov 8, 2026

Review summaries and opinions

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Categories and Ranking

Microsoft Defender for Offi...
Average Rating
8.4
Reviews Sentiment
6.8
Number of Reviews
61
Ranking in other categories
Email Archiving (2nd), Email Security (2nd), Advanced Threat Protection (ATP) (3rd), Microsoft Security Suite (8th), Secure Email Gateway (SEG) (2nd)
Trend Micro InterScan Messa...
Average Rating
7.0
Reviews Sentiment
7.1
Number of Reviews
3
Ranking in other categories
No ranking in other categories
 

Featured Reviews

Emeka Ndulu - PeerSpot reviewer
Cloud Solutions Architect at a tech services company with 201-500 employees
Improves threat visibility and response while reducing manual tasks and training users against phishing
I appreciate the attack simulation feature whereby I get to train users and educate them on how to identify phishing emails and spam emails, as well as the anti-spam protection. It gives me visibility into my threat environment and threat landscape to ensure that I am one step ahead of any likelihood of threats within my environment. I get to detect it and respond, so the threat intelligence is very effective. Microsoft security solutions save my time. It saves money because once I protect my environment, I don't lose money. It has decreased my detection time and my time to respond.
Abdul  Waris - PeerSpot reviewer
Tech Operations at Martin Dow Limited
Deploy features like DLP and BEC for enhanced security
Multiple clients are using email security. We provide solutions based on what they need, and we configure them accordingly as per the requirement With Trend Micro email security gateway, we can deploy features like DLP and BEC. It includes Office 365 protection and sandboxing. This provides…

Quotes from Members

We asked business professionals to review the solutions they use. Here are some excerpts of what they said:
 

Pros

"I would say that 90% of the spam and phishing attack emails get blocked right off the bat."
"Microsoft Defender for Office 365's most valuable features are safe attachments and safe links."
"Microsoft Defender for Office 365's most valuable feature is its performance."
"It has significantly decreased my time to detection and response."
"Overall, I would rate Microsoft Defender for Office 365 at a ten."
"The most valuable feature of Microsoft Defender for Office 365 is data backups that we can provide through ticket requests."
"The features I appreciate most about Microsoft Defender for Office 365 are admin notifications for potential threats along with protecting our Microsoft apps such as Outlook from potential phishing attacks."
"Defender helps us prioritize threats across our organization."
"The technical support services are excellent."
"The solution provides protection with its Email Track Records and Machine Manual features."
"With Trend Micro email security gateway, we can deploy features like DLP and BEC."
 

Cons

"I'd like some additional features any product can give me to protect our environment in a better way."
"If you look at other products, such as Wiz or Palo Alto's cloud, because they also have similar components in terms of how they protect cloud infrastructure or enable cloud security, Microsoft Defender for Office 365 is not up to that extent."
"We are waiting for better software to block viruses."
"Microsoft Defender for Office 365's Mac functionality requires improvement to deliver the same level of protection found on Windows devices."
"The certification training for Defender for 365 needs to be deeper and incorporate Sentinel. I took all the security courses except one, and Sentinel isn't included."
"Too many false positives and lacks an accurate capability to detect malicious SharePoint sites."
"The phishing and spam filters could use some improvement."
"Microsoft Defender for Office 365 must improve the overall management style, including the GUI. It also needs to change the filters so that it is easy to whitelist and blacklist data."
"The solution's pricing could be improved."
"There is room for improvement in content filtration, expressions, file sharing, and policy configuration."
"The product's pricing could be more flexible."
 

Pricing and Cost Advice

"I know that the product is incredibly expensive."
"From the pricing point of view, like any other product in the market, there is scope for negotiation."
"Defender is a little bit more expensive as compared to others. We are in the manufacturing environment. So, we don't have a high budget for all of our endpoint devices. Its cost is a major concern for us."
"Microsoft Defender for Office 365 is an add-on to the Office license. Many customers are purchasing this solution."
"It is much more expensive than using another solution because we have had to include some options and upgrade our license."
"Microsoft Defender for Office 365 comes with Microsoft Windows. It is free with the operating system."
"The license is expensive because the cost is based on the number of users."
"The pricing is normal. Considering its popularity, it's not overpriced."
"Trend Micro is an expensive solution."
"I rate Trend Micro InterScan Messaging Security’s pricing a seven out of ten."
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Top Industries

By visitors reading reviews
Computer Software Company
11%
Manufacturing Company
10%
Financial Services Firm
8%
Comms Service Provider
7%
Performing Arts
17%
Construction Company
10%
Outsourcing Company
9%
Manufacturing Company
8%
 

Company Size

By reviewers
Large Enterprise
Midsize Enterprise
Small Business
By reviewers
Company SizeCount
Small Business24
Midsize Enterprise11
Large Enterprise32
No data available
 

Questions from the Community

What is your experience regarding pricing and costs for Microsoft Defender for Office 365?
My experience with pricing, setup, and licensing is that it's actually quite reasonable even on the licensing side as a standalone product. It's very competitive compared to what competitor...
What needs improvement with Microsoft Defender for Office 365?
I think Microsoft Defender for Office 365 can be improved by creating more educational pieces about not just looking for malware. We are seeing a lot more malware-less emails that Defender for Offi...
What is your primary use case for Microsoft Defender for Office 365?
My main use cases for Microsoft Defender for Office 365 include email hygiene.
What is your experience regarding pricing and costs for Trend Micro InterScan Messaging Security?
The price is a bit high because the market is highly competitive. Multiple platforms are available, so we have to choose based on comparison.
What needs improvement with Trend Micro InterScan Messaging Security?
There is room for improvement in content filtration, expressions, file sharing, and policy configuration. We could decrease the price in email security gateway and cloud security services.
What is your primary use case for Trend Micro InterScan Messaging Security?
Multiple clients are using email security. We provide solutions based on what they need, and we configure them accordingly as per the requirement.
 

Also Known As

MS Defender for Office 365
InterScan Messaging Security
 

Overview

 

Sample Customers

Microsoft Defender for Office 365 is trusted by companies such as Ithaca College.
Copa Airlines, Air21, BookMyShow, Bulgarian American Credit Bank, Canadian Museum of History, CIBIL, Community National Bank, Dar Al-Handasah
Find out what your peers are saying about Proofpoint, Microsoft, Check Point Software Technologies and others in Email Security. Updated: October 2026.
921,523 professionals have used our research since 2012.